Development and tableting of directly compressible powder from electrospun nanofibrous amorphous solid dispersion

A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride.

The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of hypromellose are Methocel™ Premium K4M and Methocel™ Premium K100M in 30 and 50 % concentrations...

Biomimetic and bioactive nanofibrous scaffolds from electrospun composite nanofibers

Electrospinning is an enabling technology that can architecturally (in terms of geometry, morphology or topography) and biochemically fabricate engineered cellular scaffolds that mimic the native extracellular matrix (ECM). This is especially important and forms one of the essential paradigms in the area of tissue engineering. While biomimesis of the physical dimensions of native ECM's major co...

Development of directly compressible co-processed excipients for solid dosage forms

The tablets manufactured by direct compression method using co-processed excipient showed relatively better disintegration time and in vitro drug release, with omission of number of laborious steps as compared to tablets manufactured by conventional wet granulation method. Melt granulation technique is a potential alternative for the development of directly compressible adjuvants. Lactose and m...

Electrospun Nanofibrous Materials and Their Hydrogen Storage

Studies of Electrospun Cellulose Acetate Nanofibrous Membranes

The objective of this work was to study the feasibility of preparing cellulose acetate (CA) nanofibrous membranes by electrospinning with single solvent and their potential applying as affinity membrane. CA solutions in dichloromethane (DCM), formic acid, acetic acid and trifluoroacetic acid (TFA) were electrospun into nonwoven fiber membranes, respectively. The scanning electron microscope (SE...